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首頁(yè) /藥靶模型 /激酶靶點(diǎn) /c-Kit /c-Kit N822K/BaF3

c-Kit N822K/BaF3

CBP73279

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I. Background
KIT N822K lies within the activation loop in the protein kinase domain of the Kit protein (PMID: 24205792). N822K results in constitutive activation of Kit, increased Erk1/2 and Stat3 phosphorylation, is transforming in culture (PMID: 24205792, PMID: 31484543), leads to mislocalization of Kit to endolysosomes (PMID: 31484543), and has been identified as a secondary mutation associated with imatinib-resistance (PMID: 18488160).
 
II. Introduction

Cell Line Name:

c-Kit N822K/BaF3

Host Cell:

BA/F3

Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS+2ug/ml puromycin

Mycoplasma Status:

Negative

 
III. Representative Data

1.WB of   c-Kit N822K/BaF3


Figure 1.WB of c-Kit N822K/BaF3.

2. Sanger of c-Kit N822K/BaF3



Figure 2.Sanger of c-Kit N822K/BaF3.

3. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 c-KIT N822K(C4).

 

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藥靶模型聯(lián)系方式: 華東銷售經(jīng)理(上海):18240630236 華東銷售經(jīng)理(上海、江蘇、安徽):15715191010 華北銷售經(jīng)理:18628311252 華南銷售經(jīng)理:13823536064 華中&華西銷售經(jīng)理:18071545918 華中&西南銷售經(jīng)理:13871580511 全國(guó)銷售經(jīng)理:13816461235
診斷標(biāo)準(zhǔn)品聯(lián)系方式: 華東銷售經(jīng)理:15000320447 華北銷售經(jīng)理:18628311252 華南銷售經(jīng)理:13823536064 華中&華西銷售經(jīng)理:18071545918 華中&西南銷售經(jīng)理:13871580511 全國(guó)銷售經(jīng)理:13816461235

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