FLT3-ITD [I836del]/BaF3
CBP73243
| I. Introduction | |
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Cell Line Name： |
FLT3-ITD [I836del]/BaF3 |
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Host Cell: |
Ba/F3 |
| Stability: | 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
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Application: |
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
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Freeze Medium: |
90% FBS+10% DMSO
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Complete Culture Medium: |
RPMI-1640+10%FBS+2ug/ml puromycin
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Mycoplasma Status: |
Negative |
| II. Background | |
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FLT3, receptor-type tyrosine-protein kinase FLT3, activates Akt, Ras, and Erk pathways to regulate differentiation, proliferation, and survival of hematopoietic progenitor cells (PMID: 29316714, PMID: 28538663). Activating mutations of FLT3 are common in hematologic tumors (PMID: 19467916) and the internal tandem duplication (ITD) mutation is commonly observed in acute myeloid leukemia (PMID: 30181385). |
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| III. Representative Data | |
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1.FLT3-ITD [I836del]/BaF3
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2. Anti-proliferation assay
Figure . Anti-proliferation assay of two reference compounds on the FLT3-ITD [I836del]/BaF3 Stable Cell Line. |
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