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首頁(yè) /藥靶模型 /GPCR靶點(diǎn)細(xì)胞 /Class B1(Secretin) /PAC1R/CRE-Luc/HEK293

PAC1R/CRE-Luc/HEK293

CBP71454

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I. Background
The PAC1 receptor/PACAP-38 pathway has been proposed as a novel target for the teament of migraine. In response, Amgen developed an anti-PAC1 receptor monoclonal antibody that has completed phase 2 clinical evaluation in patients with chronic or episodic migraine.
 
II. Introduction
Host Cell:

HEK293

Stability: 20 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)
Freeze Medium: 90% FBS+10% DMSO
Culture Medium: DMEM+10%FBS+2ug/ml puromycin+200ug/ml hygromycin
Mycoplasma Status: Negative
Storage: Liquid nitrogen immediately upon delivery
Application(s):

Functional assay for PAC1R

Transducer: Gs+Gq
 
Ⅲ. Description of Host Cell Line
Organism: Human
Tissue: kidney
Morphology: Epithelial
Growth Properties: Adherent
 
Ⅳ. Representative Data

Figure 1. Recombinant PAC1R/CRE-Luc/HEK293 cell stably expressing PAC1R.

 

Figure 2.Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001(we strongly suggest to purchase from Cobioer). Dose Response of PACAP 1-38 in PAC1R/CRE-Luc HEK293 Cells(C9).


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藥靶模型聯(lián)系方式: 華東銷售經(jīng)理(上海):18240630236 華東銷售經(jīng)理(上海、江蘇、安徽):15715191010 華北銷售經(jīng)理:18628311252 華南銷售經(jīng)理:13823536064 華中&華西銷售經(jīng)理:18071545918 華中&西南銷售經(jīng)理:13871580511 全國(guó)銷售經(jīng)理:13816461235
診斷標(biāo)準(zhǔn)品聯(lián)系方式: 華東銷售經(jīng)理:15000320447 華北銷售經(jīng)理:18628311252 華南銷售經(jīng)理:13823536064 華中&華西銷售經(jīng)理:18071545918 華中&西南銷售經(jīng)理:13871580511 全國(guó)銷售經(jīng)理:13816461235

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