TREX1-KO/NFκB-SEAP/THP-1
CBP74215
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| I. Background | |
| Three-prime repair exonuclease 1 (TREX1), a major endogenous 3′–5′ DNA exonuclease, is expressed in various cell types and functions as a homodimer. TREX1, encoding a 314-amino acid protein, is a single-exon gene located on chromosome 3p21.31. TREX1 has been intensively investigated for its ability to remove cytosolic DNA and avoid inappropriate innate immune activation . | |
| II. Introduction | |
| Host Cell: | THP-1 |
| Expressed gene: | TREX1-KO |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640+ 2 mM L-glutamine+ 25 mM HEPES+ 10%FBS+ 100 U/ml penicillin+ 100 μg/ml streptomycin+ 100 μg/ml Normocin |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Homo sapiens, human |
| Tissue: | peripheral blood |
| Disease: | acute monocytic leukemia |
| Morphology: | monocyte |
| Growth Properties: | suspension |
| IV. Representative Data | |
