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首頁 /診斷試劑 /腫瘤標準品 /Mutation /AI-Edigene? POLE p.P286R Reference Standard Plus

AI-Edigene? POLE p.P286R Reference Standard Plus

CBP10685

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產品描述
產品數據庫
Introduction 
Format Genomic DNA
Description POLE, DNA polymerase epsilon catalytic subunit, mediates proofreading activity during DNA repair and replication and plays a role in genomic stability. Somatic mutations in POLE have been identified in colorectal cancer, frequently in endometrial cancer, and are often associated with high tumor mutational burden, but are less likely to be associated with DNA mismatch repair (MMR) deficiency.
   
Technical Data 
DNA Change c.857C>G
AA Change p.P286R
Mutation type Substitution - Missense
Zygosity Heterozygous
Allelic Frequency 50%
Transcript NM_006231.4
Cosmic ID COSM937332
Chr position(GRCh38) chr12-132676598-G-C
Buffer Tris-EDTA
   
Product Information 
Intended Use Research Use Only
Unit Size 1ug
Concentration Download for COA
Purofication Download for COA
DNA electrophoresis Download for COA
Sanger sequencing
Storage 2-8℃
Expiry 36 months from the date of manufacture

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